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Digoxin

Common digoxin side effects may include: nausea, diarrhea; feeling weak or dizzy; headache, weakness, anxiety, depression; or. rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 Digoxin is a medication used to manage and treat heart failure and certain arrhythmias, and abortion. It is in the cardiac glycoside class of drugs. This article outlines the indications, action, and contraindications for digoxin as a valuable agent in managing heart failure and certain arrhythmias. This activity will highlight the mechanism of action, toxicity profile, and other vital factors. Digoxin is a cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small Digoxin comes as a tablet, capsule, or pediatric elixir (liquid) to take by mouth. Digoxin is usually taken once a day. The pediatric elixir comes with a specially marked dropper for measuring the dose

Digoxin Uses, Dosage & Side Effects - Drugs

  1. يبطئ digoxin من معدل ضربات القلب، وانخفاض سرعة التوصيل من خلال العقدة الأذينية البطينية، ويقلل من درجة تفعيل الجهاز العصبي الودي ونظام الرينين أنجيوتنسين
  2. Digoxin is used to treat heart failure, usually along with other medications.It is also used to treat certain types of irregular heartbeat (such as chronic atrial fibrillation). Treating heart.
  3. الديجوكسين (بالإنجليزية: Digoxin)‏ أو ديجيتالس هو دواء يستخدم لعدد من الأمراض القلبية يتم استخراجه من النبتة الديجيتال الصوفي.يقوم الديجوكسين بزيادة انقباضية عضلة القلب وتقليل قابلية العقدة الأذينية البطينية (AV node.
  4. ديجوكسين هو دواء مستخلص من أوراق نبتة الديجيتال يُستعمل لعلاج فشل القلب الاحْتِقاني المرافق لاضطرابات معينة بنبض القلب ولإبطاء الرَّجَفان الأُذَيْني حيث يُبطئ الديجوكسين نبض القلب وبذلك تزيد فعالية كل نبضة في ضخ الدم

-Advise parents or caregivers that the symptoms of digoxin toxicity in pediatric patients may include weight loss, failure to thrive in infants, abdominal pain, and behavioral disturbances.-Instruct the patients to monitor and record their heart rate and blood pressure daily Descriptions. Digoxin is used to treat congestive heart failure, usually in combination with a diuretic (water pill) and an angiotensin-converting enzyme (ACE) inhibitor. It is also used to treat a heart rhythm problem called atrial fibrillation. Digoxin belongs to the class of medicines called digitalis glycosides Digoxin is a positive inotropic and negative chronotropic drug 7, meaning that it increases the force of the heartbeat and decreases the heart rate. 23 The decrease in heart rate is particularly useful in cases of atrial fibrillation, a condition characterized by a fast and irregular heartbeat. 13 The relief of heart failure symptoms during.

Slow digoxin loading — Slow oral digitalization, generally preferred for most patients, can be achieved by starting a maintenance dose of 0.125 to 0.25 mg daily. A steady state will be achieved after five cycles of the drug half-life (T1/2ß), which is approximately 7 to 10 days in the average subject Digoxin. Brand name: Lanoxin. Find out how digoxin treats heart problems and how to take it. About digoxin. Who can and cannot take digoxin. How and when to take digoxin. Side effects of digoxin. Pregnancy, breastfeeding and fertility while taking digoxin Digoxin is a cardiac glycoside that increases the force of myocardial contraction and reduces conductivity within the atrioventricular (AV) node. Indications and dose. Rapid digitalisation, for atrial fibrillation or flutter. By mouth. For Adult Digoxin is a substrate for cytochrome P-450 enzymes and p-glycoprotein, and many drugs are capable of increasing digoxin concentrations, including quinidine, aspirin, clarithromycin (and other macrolides), and chloramphenicol (see Appendixes I and J for list of inhibitors). Administration of phenobarbital chronically may decrease digoxin.

Digoxin is used to treat heart failure and a certain type of irregular heart beat called atrial fibrillation. It works by helping the heart to maintain a strong, steady heartbeat. It strengthens the force of your heart beat. It is one of a group of medicines known as cardiac glycosides ozanimod increases toxicity of digoxin by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis Digoxin oral tablet is a prescription medication that's used to treat atrial fibrillation (an irregular heart rhythm) and heart failure. It's a type of drug called an antiarrhythmic. Digoxin.

Digoxin is used to treat heart failure, usually along with other medications.It is also used to treat a certain type of irregular heartbeat (chronic atrial fibrillation).Treating heart failure may help maintain your ability to walk and exercise and may improve the strength of your heart. Treating an irregular heartbeat can decrease the risk for blood clots, an effect that may reduce your risk. Digoxin increases the strength and efficiency of heart contractions, and is useful in the treatment of heart failure and control the rate and rhythm of the heart. It is extracted from the leaves of a plant called digitalis lanata. Digoxin increases the force of contraction of the muscle of the heart by inhibiting the activity of an enzyme (ATPase) that controls movement of calcium, sodium, and.

Digoxin Nursing Pharmacology NCLEX (Cardiac Glycosides

Digoxin adalah obat yang digunakan untuk mengatasi beberapa jenis aritmia, salah satunya atrial fibrasi (AF) dan gagal jantung. Obat ini tidak boleh digunakan sembarangan dan hanya boleh digunakan sesuai dengan resep dokter. Digoxin merupakan obat glikosida jantung yang bekerja dengan cara memengaruhi beberapa jenis mineral yang penting dalam kerja jantung, yaitu natrium dan kalium PO. Digoxin loading oral: 500-750mcg 2 doses 6 hours apart (max 1500mcg in 24 hours) Maintenance dose. 62.5mcg - 250mcg daily. Note: when converting from the oral to the IV formulation the dosage should be reduced by 33% to take account of the difference in bioavailability Digoxin und Derivate unterscheiden sich von anderen Herzglykosiden wie z.B. Digitoxin nicht in der Pharmakodynamik, jedoch in der Pharmakokinetik. Sie haben demnach die gleiche Wirkung, werden jedoch unterschiedlich aufgenommen, umgewandelt und ausgeschieden. 6 Pharmakokinetik. Die Bioverfügbarkeit von Digoxin bei peroraler Aufnahme beträgt. Digoxin is a cardiac glycoside used as drug in case of heart problems, including congestive heart failure, atrial fibrillation or flutter, and certain cardiac arrhythmias. It has a very narrow therapeutic window of the medication. Digoxin is toxic substance with well known cardiotoxic effect. In thi

ジゴキシン(Digoxin)とはジギタリス属植物である ケジギタリス (英語版) (Digitalis lanata) の葉から抽出される強心配糖体である。 作用はジギトキシンより強く、作用時間が長い。 ジゴキシンのアグリコン(非糖部)に相当する化合物はジゴキシゲニン (Digoxigenin) である Digoxin is used to treat certain heart problems such as some arrhythmias (called atrial fibrillation and atrial flutter) and heart failure.. An arrhythmia is an irregular heartbeat - your heart may skip a beat, beat irregularly or beat at the wrong speed Digoxin can also be used in the late stages of heart failure, but this is becoming less and less common, because more effective drugs are available. How does it work? Digoxin is a type of drug called a cardiac glycoside For more information on subscription options, click below on the option that best describes you: Medical Professional. Resident, Fellow, or Student. Hospital or Institution. Group Practice. Patient or Caregiver. Subscribe. Show Graphics (0) Close Digoxin is a cardiac glycoside that increases the force of myocardial contraction and reduces conductivity within the atrioventricular (AV) node. Indications and dose. Supraventricular arrhythmias, Chronic heart failure. By mouth. For Neonate (body-weight up to 1.5 kg

Digoxin - StatPearls - NCBI Bookshel

Digoxin Immune Fab: (Minor) Digoxin immune Fab can reverse desirable as well as toxic actions of cardiac glycosides. Diltiazem: (Major) Coadministration of digoxin and diltiazem increases the serum concentration of digoxin by 20%. It is believed that diltiazem decreases renal and nonrenal clearance of digoxin Digoxin. Digoxin is a medication with the name brand of Lanoxin. It is a medication that is used for mild to moderate heart failure. It is effective for heart failure by helping the heart to beat. Use this medicine (digoxin tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Take this medicine (digoxin tablets) at the same time of day. Keep taking this medicine (digoxin tablets) as you have been told by your doctor or other health care provider, even if you feel well Digoxin is an antiarrhythmic drug that can help to maintain a proper heartbeat. An arrhythmia is an abnormal heartbeat. Digoxin treats atrial fibrillation and heart failure دواء ديجوكسين - Digoxin هو أحد الأدوية التي تستخدم لعلاج قصور القلب أو الرجفان الأذيني، ويجب أن يتمَّ استخدامه تبعاً لتعليمات الطبيب

Digoxin. 1. DIGOXIN Dr. Amlendra Phase-A Resident (BSMMU) 2. About Digoxin • It is a purified cardiac glycoside extracted from the foxglove plant, Digitalis lanata. • Its corresponding aglycone is digoxigenin, and its acetyl derivative is acetyldigoxin • It is widely used in the treatment of various heart conditions namely atrial. Description: Digoxin is a cardiac glycoside which has positive inotropic activity characterised by an increase in the force of myocardial contraction.It also reduces the conductivity of the heart through the atrioventricular (AV) node. Digoxin also exerts direct action on vascular smooth muscle and indirect effects mediated primarily by the autonomic nervous system and an increase in vagal. Digoxin ist ein pflanzlicher Naturstoff aus der Gruppe der Herzglykoside. Er wird aus den Blättern von Digitalis lanata, dem Wolligen Fingerhut, gewonnen. Der Wirkstoff wird zur Behandlung von Herzschwäche und bestimmten Formen von Herzrhythmusstörungen angewendet

Wirkmechanismus. Digoxin ist ein mittellangwirkendes Herzglykosid (Cardenolid). Es wirkt: positiv inotrop (gesteigerte Kontraktionskraft und -geschwindigkeit bei verzögerter Relaxationszeit),; negativ chronotrop (Abnahme der Schlagfrequenz),; negativ dromotrop (Verzögerung der Erregungsleitung) und; positiv bathmotrop (gesteigerte Erregbarkeit, besonders im Bereich der Kammermuskulatur) DIGOXIN Maureen S. Boro and Michael E. Winter Digoxin is an inotropic agent primarily used to treat congestive heart failure (CHF) and atrial fibrillation. It is incompletely absorbed and once ab-sorbed, a substantial fraction is cleared by the kidneys. In the acute care set-ting, historically digoxin loading doses of 1 mg/70 kg were administere

Digoxin is derived from the leaves of a digitalis plant and is used to treat heart failure. Digoxin is also used to treat atrial fibrillation, a heart rhythm disorder of the atrium (the upper. A cardenolide glycoside that is digitoxin <stereo>beta</stereo>-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, <ital>Digitalis lanata</ital>, it is used to control ventr icular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small Digoxin is available in three formulations with different doses: Tablets: 62.5 micrograms (mcg), 125 mcg, 187.5 mcg, and 250 mcg 5. Oral solution: 0.05 mg (50 mcg) per 1 milliliter (mL) dose 17. IV injection: 0.5 mg (500 mcg) per 2 mL dose for adults and 0.1 mg (100 mcg) per 2 mL dose for children 18 A digoxin test checks how much digoxin you have in your blood. Digoxin is a type of medicine called a cardiac glycoside. It is used to treat certain heart problems, although much less often than in the past digoxin: [noun] a poisonous cardiotonic steroid C41H64O14 obtained from a foxglove (Digitalis lanata) and used especially to treat atrial fibrillation

Digoxin. 100 INR Get latest price. MOQ: 1 Kilograms. Molecular Weight:780.938 Grams (g) Purity:95%. Usage:Digoxin is used to treat heart failure, usually along with other medications. It is also used to treat certain types of irregular heartbeat (such as chronic atrial fibrillation). Treating heart failure may help maintain your ability to walk. Digoxin (NSC 95100) is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure. CAS No. 20830-75-5 Digoxin has two major mechanisms of action that can help in the treatment of heart failure or atrial fibrillation: 1. Increasing the force of heart contractions: Digoxin inhibits certain pumps in the cardiac cell membranes, reducing the movement of sodium from the inside of cells to the outside of cells. By keeping sodium within the cells, it. Digoxin is one of the cardiac (or digitalis) glycosides, a closely related group of drugs having in common specific effects on the myocardium. These drugs are found in a number of plants. Digoxin is extracted from the leaves of Digitalis lanata. The term digitalis is used to designate the whole group of glycosides The serum digoxin concentration: ten questions to ask. Am Fam Physician. 1997 Aug;56(2):495-503, 509-10. Cheng JW, Charland SL, Shaw LM, Kobrin S, Goldfarb S, Stanek EJ, Spinler SA. Is the volume of distribution of digoxin reduced in patients with renal dysfunction? Determining digoxin pharmacokinetics by fluorescence polarization immunoassay

Digoxin C41H64O14 - PubChe

Digoxin is a cardiac glycoside indicated for: Treatment of mild to moderate heart failure in adults. ( 1.1) Control of resting ventricular rate in adults with chronic atrial fibrillation. ( 1.2) DOSAGE AND ADMINISTRATION. Digoxin dose is based on patient-specific factors (age, lean body weight, renal function, etc.) Digoxin ist eine natürlich in Form von Digitalisglycosiden in Fingerhut-Arten vorkommende chemische Verbindung mit Wirkung auf den Herzmuskel.Digoxin zählt zu den endogenen Glycosiden, die als Hormone in Säugetieren fungieren. Aus pflanzlichen, primären Digitalisglycosiden kann Digoxin durch enzymatische Hydrolyse als Sekundärglycosid gewonnen werden Digoxin is a cardiac glycoside extracted from foxglove leaves. It is used in heart failure because of its ability to increase the force of myocardial contraction (positive inotropy) and, simultaneously, decrease oxygen consumption. Digoxin binds to and inhibits the sodium/potassium-ATPase (sodium pump) within the plasma membrane of cardiac. Digoxin in atrial fibrillation. In patients with AF, the primary effect of digoxin is slowing down atrioventricular (AV) conduction, leading to a reduction in ventricular response at rest, but much less so during exercise. 2, 4 This effect of digoxin is due to enhancement of vagal tone, and is less prominent during increased sympathetic activity, such as exercise. 10 Given the fact that higher.

• Digoxin is the most widely used cardiac glycoside. Many oral forms and a parenteral form are available, facilitating use of the drug in both acute and long-term clinical settings. ALERT Don't confuse digoxin with doxepin, desoxyn, or digitoxin. ALERT Excessive slowing of heart rate (60 beats/ minute or less) may be a sign of digitalis. digoxin tablets will degrade 40% or more of the ingested dose. As a result, certain antibiotics may increase the absorption of digoxin in such patients. Although inactivation of these bacteria by antibiotics is rapid, the serum digoxin concentration will rise at a rate consistent with the elimination half-life of digoxin Positive inotropic effect (increases force of myocardial contraction), prolongs refractory period, ↓ conduction through SA and AV nodes. Essentially digoxin is given to increase cardiac output and slow the rate Electrical cardioversion (a medical procedure)—Dose of digoxin may be reduced 1 to 2 days prior to electrical cardioversion of atrial fibrillation to avoid worsening of the condition. Heart disease (e.g., amyloid heart disease, AV block, constrictive pericarditis, cor pulmonale, heart attack, hypertrophic cardiomyopathy, restrictive. 1. Digoxin preparations must be stored in tightly covered, light resistant containers at room temp. 2. FOLLOW CLOSELY (especially in patients receiving diuretics or amphotericin) for decreased serum potassium (K), magnesium (Mg), or thyroxine (T4) along with increased calcium (Ca) will increase digoxin toxicity at a given level

Digoxin Toxicity • LITFL • ECG Library Toxicology

Digoxin therapy has long been used to treat heart failure; however, its effectiveness was not completely known until recently. Results of the Digitalis Investigation Group trial showed that adding. Digoxin is a drug used to treat heart failure and abnormal heart rhythms. Heart failure, including congestive heart failure (CHF), causes the heart to become less effective at circulating blood. As a result, blood backs up into the legs, hands, feet, lungs and liver, causing swelling, shortness of breath, and fatigue Digoxin is indicated in patients with atrial fibrillation, with or without HF, and a rapid ventricular response. Irrespective of the indication, a low dose of 0.125 mg should be used. Digoxin should be avoided or used with extreme caution in the very elderly or in patients with severe conduction abnormalities, acute coronary syndromes, or renal. digoxin and Fab were determined (see Clinical Pharmacokinetics for Fab pharmacokinetic parameters). The primary outcome measure was the serum level of free (unbound) digoxin Digoxin Toxicity Definition. Digoxin is a medicine used to treat heart failure and rhythm problems. Digoxin toxicity (DT) is an overdose of this medicine

digoxin intoxication Most cases of digoxin intoxication are chronic and unintentional, due to gradual accumulation of digoxin over time. Precipitating factors for chronic intoxication may include the following: (a) Digoxin is renally cleared, so any cause of kidney injury may cause accumulation Digoxin. Nogle lægemidler er forbundet med større risiko i bestemte situationer. De står for en stor del af de utilsigtede hændelser, der opstår på grund af medicinfejl, og som medfører alvorlige konsekvenser for patienterne. Bedre forståelse af de særlige risici ved disse lægemidler kan derfor bidrage til at forbedre patientsikkerheden

Both digoxin and amiodarone can increase the risk of bradycardia. Amiodarone is predicted to moderately increase the exposure to digoxin. Manufacturer advises monitor and adjust digoxin dose. Severity of interaction: Severe Digoxin Injection can be administered undiluted or diluted with a 4-fold or greater volume of Sterile Water for Injection, 0.9% Sodium Chloride Injection, or 5% Dextrose Injection. The use of less than a 4-fold volume of diluent could lead to precipitation of the digoxin. Immediate use of the diluted product is recommended DIGOXIN. 1. Từ cơ chế đến chỉ định điều trị BS NGUYỄN XUÂN TUẤN ANH. 3. Thuộc nhóm glycoside trợ tim, được sử dụng để tăng sức co bóp của cơ tim. Dược lý Y3 - 2013 3. 4. Nguyên nhân suy tim : bệnh mạch vành, tăng HA, bệnh van tim Điều trị : lợi tiểu, ức chế hệ RAA, ức. The Emit® 2000 Digoxin Assay is a homogeneous enzyme immunoassay intended for use in the quantitative analysis of digoxin in human serum or plasma. These reagents are packaged specifically for use on a variety of AU® Clinical Chemistry Systems. 2 SUmmARy Monitoring serum digoxin concentrations, along with careful clinical assessment, is the mos Be sure the patient is not on digitoxin instead of digoxin. Digitoxin is also an active component of digitalis leaf. The 2013 ACCF/HCA Guidelines for Management of Heart Failure suggest a therapeutic range of 0.5 -0.9 ng/mL for digoxin. Ninety percent of nontoxic patients have levels ≤2.0 ng/mL, 87% of toxic patients have levels >2.0 ng/mL

digoxin: see digitalis digitalis, any of several chemically similar drugs used primarily to increase the force and rate of heart contractions, especially in damaged heart muscle دواء ديجوكسين Digoxin لعلاج إضطرابات القلب مثل قصور القلب والرجفان الأذيني، ومِن الجدير بالذكر أن الدواء مستخرج مِن نبتة الديجيتال الصوف Digoxin is a cardiac glycoside which has positive inotropic activity characterized by an increase in the force of myocardial contraction. It also reduces the conductivity of the heart through the atrioventricular (AV) node. Digoxin also exerts direct action on vascular smooth muscle and indirect effects mediated primarily by the autonomic. Digoxin toxicity is a clinical diagnosis that relies in part on ECG findings such as signs of increased automaticity and atrioventricular node blockade (premature ventricular contractions, slowed ventricular response). Serum digoxin concentration is usually greater than the therapeutic range of 0.5 to 0.9 nanograms/mL, but may not be elevated

Digoxin: MedlinePlus Drug Informatio

Heart Failure- Clinical TherapeuticsRed Alert: What You Need for the NCLEX - QD Nurses

Digoxin - altibbi.co

Digoxin is a drug that is used to treat heart failure, a condition in which the heart muscle is weak and unable to pump blood effectively to the rest of the body. Digoxin can also be used to treat atrial fibrillation. Digoxin can be given to patients with heart failure in order to make more calcium available so that a stronger heart contraction can be generated Digitoxin is a cardiac glycoside used for the treatment of heart failure and certain kinds of heart arrhythmia.It is a phytosteroid and is similar in structure and effects to digoxin, though the effects are longer-lasting.Unlike digoxin, which is eliminated from the body via the kidneys, it is eliminated via the liver, and so can be used in patients with poor or erratic kidney function Caution is advised. Vital signs should be monitored closely. Signs and Symptoms of Digoxin Exposure: Acute digoxin ingestion may produce the following signs and symptoms: nausea, vomiting, headache, lethargy, drowsiness, confusion, slowed pulse, varying degrees of heart block, and heart arrhythmias MedCram subscribers: Visit https://www.boardvitals.com/medcram for a discount on a massive library of medical board questions like this one.Dr. Roger Seheult..

Digoxin Oral: Uses, Side Effects, Interactions, Pictures

Digoxin requirements in older adult may change and a formerly therapeutic dose can become toxic. Observe for signs and symptoms of toxicity. In adults and older children, first symptoms of toxicity usually include abdominal pain, anorexia, nausea, vomiting, visual disturbances,. Digoxin-specific antibody Fab is a specific treatment for digoxin toxicity and is very effective. Rapid reversal of the complications that are associated with serious poisoning by digoxin, digitoxin and related glycosides has followed I.V. administration of digoxin-specific (ovine) antibody fragments (Fab)

ديجوكسين - ويكيبيدي

Digoxin toxicity may manifest with nausea, vomiting, dizziness, headache, weakness, syncope, confusion, disorientation, delirium, hallucinations, and seizures in addition to cardiac dysrhythmias. Therefore, elderly patients who are taking digoxin and who have mental status changes should be evaluated for digoxin toxicity Digoxin is effective for rate control in patients with atrial fibrillation, but its influence on mortality rates is a source of controversy. The use of digoxin is limited because the drug has a narrow therapeutic index and requires close monitoring. Digoxin can cause many adverse events, is involved in multiple drug interactions, and can result. Digoxin (Lanoxin) is a medicine used for various heart conditions including arrhythmias and congestive heart failure. It is used to improve the strength and efficiency of the heart, or to control the rate and rhythm of the heartbeat. This leads to better circulation (blood flow) and less swelling of hands and ankles

Toxicology pgy 1+2 2013

ديجوكسين: الاستخدامات وأبرز المحاذير - ويب ط

Drug Interactions with Digoxin: The Role of P-glycoprotein. One of the most widely studied drug interactions is the interaction between digoxin and quinidine. Patients who receive the combination almost always will have a significant elevation in their digoxin plasma concentrations and can suffer digoxininduced toxicity, including arrhythmias. Digoxin has a large volume of distribution, being 6-10 L/kg in adults, 10 L/kg in neonates, and as much as 16L/kg in infants and toddlers. At therapeutic levels, the elimination half-life is 36 hours. In acute digoxin intoxication in toddlers and children, the average plasma half-life is 11 hours Digoxin, Metformin, Rosuvastatin: Cmax (maximum measured concentration of the analyte in plasma) [ Time Frame: up to 96 hours ] Secondary Outcome Measures : Furosemide: AUC0-inf (area under the concentration-time curve of the analyte in plasma over the time interval from 0 extrapolated to infinity) [ Time Frame: up to 36 hours Effectively, digoxin is excreted mainly unaltered in the urine, with up to 80% of a dose excreted in urine in 7 days being 27% of the dose excreted in the first 24 h . Digoxin can be found as the result of its administration or due to metabolism since it is a metabolite of deslanoside, digitoxin, lanatoside C and metildigoxin Digoxin is the common name for cardiac glycosides. Digoxin includes: Lanoxin ® Toloxin ® If your prescription isn't listed, your pharmacist is the best source for more information. What does it do? You might take digoxin if you have a heart rhythm disorder, heart failure or a weakened heart muscle. Helps your heart pump with more force

Generic Substitution of Narrow Therapeutic Index Drugs

Digoxin is a cardiac glycoside used for treating adults with mild to moderate congestive heart failure and for treating abnormally rapid atrial rhythms (atrial fibrillation, atrial flutter, atrial tachycardia).It also is used for increasing myocardial contractility in pediatric patients with heart failure Thorough patient teaching is essential to protect patient safety. Most patients receive digoxin on a long-term basis and so are at risk for toxicity or subtherapeutic dosing. Advise the patient about how to take digoxin: • If you miss a dose, do not double dose. Skip the dose if the next dose is due in less than 12 hours الجرعة: - للبالغين: جرعة التحميل: 500-1000 ميكروغرام. يمكن تطبيق جرعة التحميل إما بالتسريب الوريدي كجرعة واحدة تعطي خلال ساعتين على الأقل أو كجرعات مقسمة بالحقن الوريدي البطيء تعطى خلال 5 دقائق. Heart Failure. Digoxin possesses many characteristics of a beneficial drug for heart failure. It is the only oral inotrope that does not increase long-term mortality in chronic heart failure and has few side effects when dosed appropriately on the basis of serum concentration. 2 Digoxin does not lower blood pressure or adversely affect renal function or electrolytes. 2 Accordingly, it is easy. Although digoxin is one of the most commonly prescribed drugs for the treatment of heart failure, there is uncertainty about its long-term efficacy and safety. 1-3 Several recent short-term.